What's new with us?

Cell Culture webinar
Technology

Registration for Webinar is open : “ADVANCED SCAFFOLDS FOR BIOMEDICAL APPLICATIONS”

Join the webinar series on: “ADVANCED SCAFFOLDS FOR BIOMATERIAL APPLICATIONS”

 

We have prepared for you this special webinar in collaboration with University College London, Fraunhofer IBG, University of Liverpool and many others. Webinar will be basically focused on Cell Culture methods and scaffolding systems for bone and cartilage regeneration. If you are interested in advanced biomaterials, cell culture and regenerative medicine – please send us your registration. There is no prior knowledge required.

 

Looking forward to see you participating on webinar ADVANCED SCAFFOLDS FOR BIOMETRIAL APPLICATIONS. Do not miss your chance and register at:

 

More info and registration-> https://lnkd.in/ggixQxJ

 

Cell Culture webinar

Cell Culture and Biomaterials Webinar

Technology

Advanced Emulsion Electrospinning

InoCure’s researchers are advancing the emulsion electrospinning method for controlled release of biomolecule-based active pharmaceutical ingredients (APIs). Emulsion electrospinning allows the encapsulation of high quantities of the biomolecules in the core of the nanofibers, preserving their structure and activity. For sustained release applications, water in oil emulsions are used. In this case, biomolecules, such as proteins, are dissolved in the water together with other waster soluble molecules. Then the water phase is mixed with the polymers dissolved in organic solvents (e.g. polycaprolactone in chloroform) and emulsified using homogenizers. During the electrospinning, produce water droplets form the core of the nanofibers (red in confocal microscopy images and illustration) which encapsulates and protects the active molecule. The shell of the fibres acts as a barrier, limiting the release of the active molecules. Compared to the coaxial-spinning, high-throughput (5 gr/hr using the lab-scale InoSpin) production of nanofibers is possible. The formulation and the process are developed in three stages:

  1. Optimization of the emulsion stability. For this, various polymer composition, surfactants and their ratios, preparation methods are being tested. Stability of the emulsion is evaluated visually, by observing the phase separation. The formulation that are sufficiently stable (no signs of separation in one hour) are used for high throughput electrospinning.
  2. Optimization of the emulsion electrospinning. Stable emulsions are processed into nanofibrous membranes using the high-throughput (>30 ml/hr) emulsion electrospinning. Depending on the formulation, continuous or separated core is formed. The electrospinning process is optimized to ensure maximum fibre homogeneity, and quality.
  3. Optimization of the release rate. Once suitable electrospinning parameters are found, the formulation is further adjusted to optimize the release rate of the active ingredient. In this case, design of experiment is used to find the optimum ratios of polymers and surfactants to achieve the needed loading and release of the active pharmaceutical ingredient.

The optimized formulation can then be used for encapsulation and delivery of various molecules with only slight adjustments in formulation and process.

 

Technology

Development and optimization of the electrospinning device InoSPIN

Electrospinning is currently the dominant electrohydroelectrospinning development dynamic technique to fabricate thin fibers, thanks to its simplicity and relatively low cost.

Nowadays, fibrous materials show a great usefulness in many applications (drug delivery systems, textile, environmental remediation). Nanofibers have become extremely appealing due to their unique properties, mainly highly porous structure and large surface – volume ratio. Electrospinning is currently the dominant electrohydroelectrospinning development dynamic technique to fabricate thin fibers, thanks to its simplicity and relatively low cost. It is based on a high voltage applied between a metallic needle or a needleless electrode, and a collector. The strong external voltage deforms the liquid coming out of the nozzle into a jet. However, an efficient production of nanofibers by electrospinning remains challenging.

Development of electrospinning technique includes: i) theoretical model design and a comprehensive analysis its properties based on numerical simulations, ii) verification preliminary results in practical use. So far, a crucial relation between the geometry of the spinning electrode and formed nanofibers has been observed. Indeed, our work plays a significant role in selecting a proper electrospinning configuration, depending on the application and desired results.

Electrospinning device InoSPIN

Technology

InoCURE is one of the winners from Regional Innovation Scheme countries receive EUR 25 000 in smart money, training and mentoring!

EIT Health InnoStars Awards 2019 boost start-ups from RIS countries.InoCURE Is one of the winners .

EIT Health InnoStars Awards 2019 - RIS

The 15 winners from Regional Innovation Scheme countries receive EUR 25 000 in smart money, training and mentoring

The Regional Innovation Scheme Programme (RIS) focuses on countries from Central, Eastern and Southern Europe. The 15 EIT Health InnoStars Awards winner are still developing in terms of healthcare innovation. They will receive EUR 25 000 in funding, as well as training and mentoring support.

EIT Health InnoStars Awards

In the third year of the InnoStars Awards, the winners were chosen from 116 high-quality contestants based in the 13 RIS countries – which have more moderate levels of innovation than other European countries.

Selected by a panel of experts, the winning start-ups include five from Portugal, two from Poland, two from Hungary, two from Latvia, one from the Czech Republic, one from Lithuania, one from Italy and one from Romania.

They will receive EUR 25 000 of smart money, individual mentoring for four months, and the opportunity to participate in two bootcamps in Europe. EIT Health InnoStars will also organise three validation interviews with potential customers, investors and partners for the award winners. After the four-month programme, 10 finalists will be selected to participate in the InnoStars Awards final pitch in November, to compete for the three top prizes: an additional EUR 25 000, EUR 15 000, or EUR 10 000 in funding.

Technology

New scientific article published: Drug delivery to retinal photoreceptors

The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different options for drug delivery to the photoreceptor cells

Contact Us
close slider